He improved his position after the performance in the Australian Open Tennis Championships. On January 23, Istomin lost to the Bulgarian Grigor Dimitrov (13) in the match of the fourth round of the Australian Open, which was won by the Swiss Roger Federer (10). However, the Uzbekistan tennis player enabled to make a sensation by beating second-ranked Novak Djokovic of Serbia. He also defeated Croat Ivan Dodig (158) and Pablo Carreno-Busta (26) of Spain.
Triumphant performance of Istomin brought him $220,000 prize money and went up to 37 positions in the ATP ranking.
The best result of Denis Istomin in the ATP rankings for the whole of his career was the 36th position.